G-protein beta-3 subunit genotype predicts enhanced benefit of fixed-dose isosorbide dinitrate and hydralazine: results of A-HeFT.
Identifieur interne : 000256 ( France/Analysis ); précédent : 000255; suivant : 000257G-protein beta-3 subunit genotype predicts enhanced benefit of fixed-dose isosorbide dinitrate and hydralazine: results of A-HeFT.
Auteurs : Dennis M. Mcnamara [États-Unis] ; Anne L. Taylor [États-Unis] ; S William Tam [États-Unis] ; Manuel Worcel [France] ; Clyde W. Yancy [États-Unis] ; Karen Hanley-Yanez [États-Unis] ; Jay N. Cohn [États-Unis] ; Arthur M. Feldman [États-Unis]Source :
- JACC. Heart failure [ 2213-1787 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Afro-Américains (génétique), Analyse de variance, Association médicamenteuse, Dinitrate isosorbide (usage thérapeutique), Durée du séjour, Dysfonction ventriculaire gauche (génétique), Défaillance cardiaque (génétique), Défaillance cardiaque (mortalité), Défaillance cardiaque (traitement médicamenteux), Femelle, Génotype, Humains, Hydralazine (usage thérapeutique), Mâle, Polymorphisme de nucléotide simple (génétique), Protéines G hétérotrimériques (génétique), Qualité de vie, Résultat thérapeutique, Survie sans rechute, Vasodilatateurs (usage thérapeutique).
- MESH :
- génétique : Afro-Américains, Dysfonction ventriculaire gauche, Défaillance cardiaque, Polymorphisme de nucléotide simple, Protéines G hétérotrimériques.
- mortalité : Défaillance cardiaque.
- traitement médicamenteux : Défaillance cardiaque.
- usage thérapeutique : Dinitrate isosorbide, Hydralazine, Vasodilatateurs.
- Adulte d'âge moyen, Analyse de variance, Association médicamenteuse, Durée du séjour, Femelle, Génotype, Humains, Mâle, Qualité de vie, Résultat thérapeutique, Survie sans rechute.
English descriptors
- KwdEn :
- African Americans (genetics), Analysis of Variance, Disease-Free Survival, Drug Combinations, Female, Genotype, Heart Failure (drug therapy), Heart Failure (genetics), Heart Failure (mortality), Heterotrimeric GTP-Binding Proteins (genetics), Humans, Hydralazine (therapeutic use), Isosorbide Dinitrate (therapeutic use), Length of Stay, Male, Middle Aged, Polymorphism, Single Nucleotide (genetics), Quality of Life, Treatment Outcome, Vasodilator Agents (therapeutic use), Ventricular Dysfunction, Left (genetics).
- MESH :
- chemical , genetics : Heterotrimeric GTP-Binding Proteins.
- chemical , therapeutic use : Hydralazine, Isosorbide Dinitrate, Vasodilator Agents.
- chemical : Drug Combinations.
- drug therapy : Heart Failure.
- genetics : African Americans, Heart Failure, Polymorphism, Single Nucleotide, Ventricular Dysfunction, Left.
- mortality : Heart Failure.
- Analysis of Variance, Disease-Free Survival, Female, Genotype, Humans, Length of Stay, Male, Middle Aged, Quality of Life, Treatment Outcome.
Abstract
The purpose of this study was to evaluate the influence of the guanine nucleotide-binding proteins (G-proteins), beta-3 subunit (GNB3) genotype on the effectiveness of a fixed-dose combination of isosorbide dinitrate and hydralazine (FDC I/H) in A-HeFT (African American Heart Failure Trial).
DOI: 10.1016/j.jchf.2014.04.016
PubMed: 25306451
Affiliations:
- France, États-Unis
- Illinois, Massachusetts, Minnesota, Pennsylvanie, État de New York, Île-de-France
- Paris
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- to stream Ncbi, to step Checkpoint: 003996
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- to stream Main, to step Exploration: 002C76
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Links to Exploration step
pubmed:25306451Le document en format XML
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Mcnamara</name><affiliation wicri:level="2"><nlm:affiliation>Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address: mcnamaradm@upmc.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh Medical Center, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Taylor, Anne L" sort="Taylor, Anne L" uniqKey="Taylor A" first="Anne L" last="Taylor">Anne L. 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Heart failure</title><idno type="eISSN">2213-1787</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>African Americans (genetics)</term><term>Analysis of Variance</term><term>Disease-Free Survival</term><term>Drug Combinations</term><term>Female</term><term>Genotype</term><term>Heart Failure (drug therapy)</term><term>Heart Failure (genetics)</term><term>Heart Failure (mortality)</term><term>Heterotrimeric GTP-Binding Proteins (genetics)</term><term>Humans</term><term>Hydralazine (therapeutic use)</term><term>Isosorbide Dinitrate (therapeutic use)</term><term>Length of Stay</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide (genetics)</term><term>Quality of Life</term><term>Treatment Outcome</term><term>Vasodilator Agents (therapeutic use)</term><term>Ventricular Dysfunction, Left (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Afro-Américains (génétique)</term><term>Analyse de variance</term><term>Association médicamenteuse</term><term>Dinitrate isosorbide (usage thérapeutique)</term><term>Durée du séjour</term><term>Dysfonction ventriculaire gauche (génétique)</term><term>Défaillance cardiaque (génétique)</term><term>Défaillance cardiaque (mortalité)</term><term>Défaillance cardiaque (traitement médicamenteux)</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Hydralazine (usage thérapeutique)</term><term>Mâle</term><term>Polymorphisme de nucléotide simple (génétique)</term><term>Protéines G hétérotrimériques (génétique)</term><term>Qualité de vie</term><term>Résultat thérapeutique</term><term>Survie sans rechute</term><term>Vasodilatateurs (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Heterotrimeric GTP-Binding Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Hydralazine</term><term>Isosorbide Dinitrate</term><term>Vasodilator Agents</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Drug Combinations</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Heart Failure</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>African Americans</term><term>Heart Failure</term><term>Polymorphism, Single Nucleotide</term><term>Ventricular Dysfunction, Left</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Afro-Américains</term><term>Dysfonction ventriculaire gauche</term><term>Défaillance cardiaque</term><term>Polymorphisme de nucléotide simple</term><term>Protéines G hétérotrimériques</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Heart Failure</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Défaillance cardiaque</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Défaillance cardiaque</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Dinitrate isosorbide</term><term>Hydralazine</term><term>Vasodilatateurs</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Disease-Free Survival</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Length of Stay</term><term>Male</term><term>Middle Aged</term><term>Quality of Life</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Analyse de variance</term><term>Association médicamenteuse</term><term>Durée du séjour</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Mâle</term><term>Qualité de vie</term><term>Résultat thérapeutique</term><term>Survie sans rechute</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The purpose of this study was to evaluate the influence of the guanine nucleotide-binding proteins (G-proteins), beta-3 subunit (GNB3) genotype on the effectiveness of a fixed-dose combination of isosorbide dinitrate and hydralazine (FDC I/H) in A-HeFT (African American Heart Failure Trial).</div></front></TEI><affiliations><list><country><li>France</li><li>États-Unis</li></country><region><li>Illinois</li><li>Massachusetts</li><li>Minnesota</li><li>Pennsylvanie</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Mcnamara, Dennis M" sort="Mcnamara, Dennis M" uniqKey="Mcnamara D" first="Dennis M" last="Mcnamara">Dennis M. Mcnamara</name></region><name sortKey="Cohn, Jay N" sort="Cohn, Jay N" uniqKey="Cohn J" first="Jay N" last="Cohn">Jay N. Cohn</name><name sortKey="Feldman, Arthur M" sort="Feldman, Arthur M" uniqKey="Feldman A" first="Arthur M" last="Feldman">Arthur M. Feldman</name><name sortKey="Hanley Yanez, Karen" sort="Hanley Yanez, Karen" uniqKey="Hanley Yanez K" first="Karen" last="Hanley-Yanez">Karen Hanley-Yanez</name><name sortKey="Tam, S William" sort="Tam, S William" uniqKey="Tam S" first="S William" last="Tam">S William Tam</name><name sortKey="Taylor, Anne L" sort="Taylor, Anne L" uniqKey="Taylor A" first="Anne L" last="Taylor">Anne L. Taylor</name><name sortKey="Yancy, Clyde W" sort="Yancy, Clyde W" uniqKey="Yancy C" first="Clyde W" last="Yancy">Clyde W. Yancy</name></country><country name="France"><region name="Île-de-France"><name sortKey="Worcel, Manuel" sort="Worcel, Manuel" uniqKey="Worcel M" first="Manuel" last="Worcel">Manuel Worcel</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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